Enlightening Ways to Relax Airway Smooth Muscle: Opsins
نویسندگان
چکیده
منابع مشابه
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.
Epoxyeicosatrienoic acids (EETs) are produced from arachidonic acid via the cytochrome P-450 epoxygenase pathway. EETs are able to modulate smooth muscle tone by increasing K(+) conductance, hence generating hyperpolarization of the tissues. However, the molecular mechanisms by which EETs induce smooth muscle relaxation are not fully understood. In the present study, the effects of EETs on airw...
متن کاملAirway smooth muscle relaxation.
Bronchodilators are important agents in the treatment of asthma and chronic obstructive airways disease. Beta agonists, theophyllines, and antimuscarinic agents are the main drugs in current use, but others are under investigation. Although other actions may be important, these drugs produce bronchodilation either by a direct effect on airway smooth muscle or by inhibiting neural pathways. As o...
متن کاملDiadenosine polyphosphates directly relax porcine coronary arterial smooth muscle.
By use of front-surface fluorometry and fura-2-loaded medial strips of the porcine coronary artery, cytosolic Ca++ concentration ([Ca++]i) and force development were monitored simultaneously to determine the mechanisms of vasorelaxation induced by the diadenosine polyphosphates (APnA) diadenosine 5',5'''-P1, P4-tetraphosphate (AP4A) and diadenosine 5',5'''-P1,P5-pentaphosphate (AP5A). APnA conc...
متن کاملHalothane increases smooth muscle protein phosphatase in airway smooth muscle.
BACKGROUND Halothane relaxes airway smooth muscle, in part, by decreasing the force produced for a given intracellular [Ca(2+)] (i.e., Ca(2+) sensitivity) during muscarinic stimulation, an effect produced by a decrease in regulatory myosin light-chain (rMLC) phosphorylation. The authors tested the hypothesis that halothane reduces rMLC phosphorylation during muscarinic stimulation at constant i...
متن کاملAirway smooth muscle and asthma.
The airway smooth muscle is the key determinant of airway narrowing in asthma but its function in the absence of disease is unknown. Evidence for an intrinsic abnormality in the muscle in asthma is only just emerging. The airway smooth muscle is not merely a contractile cell, but also one which determines the composition of, and interacts with the extracellular matrix, and which may participate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2021
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2020-0468ed